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This two volume set LNCS 10177 and 10178 constitutes the refereed proceedings of the 22nd International Conference on Database Systems for Advanced Applications, DASFAA 2017, held in Suzhou, China, in March 2017. The 73 full papers, 9 industry papers, 4 demo papers and 3 tutorials were carefully selected from a total of 300 submissions. The papers are organized around the following topics: semantic web and knowledge management; indexing and distributed systems; network embedding; trajectory and time series data processing; data mining; query processing and optimization; text mining; recommendation; security, privacy, senor and cloud; social network analytics; map matching and spatial keywords; query processing and optimization; search and information retrieval; string and sequence processing; stream date processing; graph and network data processing; spatial databases; real time data processing; big data; social networks and graphs. ...

Topics covered in this volume (large deviations, differential geometry, asymptotic expansions, central limit theorems) give a full picture of the current advances in the application of asymptotic methods in mathematical finance, and thereby provide rigorous solutions to important mathematical and financial issues, such as implied volatility asymptotics, local volatility extrapolation, systemic risk and volatility estimation. This volume gathers together ground-breaking results in this field by some of its leading experts. Over the past decade, asymptotic methods have played an increasingly important role in the study of the behaviour of (financial) models. These methods provide a useful alternative to numerical methods in settings where the latter may lose accuracy (in extremes such as small and large strikes, and small maturities), and lead to a clearer understanding of the behaviour of models, and of the influence of parameters on this behaviour. Graduate students, researchers and pr...

This new edition to the classic book by ggplot2 creator Hadley Wickham highlights compatibility with knitr and RStudio. ggplot2 is a data visualization package for R that helps users create data graphics, including those that are multi-layered, with ease. With ggplot2, it's easy to: produce handsome, publication-quality plots with automatic legends created from the plot specification superimpose multiple layers (points, lines, maps, tiles, box plots) from different data sources with automatically adjusted common scales add customizable smoothers that use powerful modeling capabilities of R, such as loess, linear models, generalized additive models, and robust regression save any ggplot2 plot (or part thereof) for later modification or reuse create custom themes that capture in-house or journal style requirements and that can easily be applied to multiple plots approach a graph from a visual perspective, thinking about how each component of the data is represented on the final ...

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells. Product details ...